Destroying a temple will destroy all of the associated houses.
It is unlikely for a base to be heavily invested in Hades Houses, that being said, if this is the case, prioritizing Hades' Temple might be a good idea.
Defensive
As the enemy must destroy all of your temples to win, place the temple in a well-defended or hard-to-reach location.
Hades' power is specialized against attackers that use kiting in their strategy.
Skeletons that reanimate have a higher movement speed than regular units so can be quite useful for putting pressure on opponent gods that are moving around your base.